Document Type: Original Research

Authors

1 Ph.D., Department of Medical Physics, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

2 M.S. student, Department of Medical Physics, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

3 Department of Radiology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract

Aim: CT number (HU) and linear attenuation coefficient contain useful information which  can be determined during usual CT scanning for the prediction of breast cancerous cells existence based on hemoglobin concentration.Methods: This study used breast phantom containing major and minor vessels with diameters of 10 and 5 mm, respectively. The major vessels are filled by water, fat, hemoglobin (Hb) as a normal and 4× concentration of hemoglobin (4×Hb) as a cancerous breast cells, then scanned by single slice CT (GE, Hi Speed) 120 kVp, 100 mA for the determination of linear attenuation coefficient (µL).Results: The CT numbers were for water (-7 to +7 HU), Hb (22±6 HU) and 4×Hb (80±4 HU). The difference between Hb and 4×Hb was significant (p <0.000). Minimum µL was 0.1190±0.00680 cm-1 for fat and maximum was 0.1449±0.00794 cm-1 for 4×Hb. Conclusion: The study of CT number and linear attenuation coefficient of different concentration of Hb provides a possibility for early predicting of breast cancerous cells existence (4×Hb).

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