@article { author = {Ebrahimnejad Gorji, K and Abedi Firouzjah, R and Khanzadeh, F and Abdi-Goushbolagh, N and Banaei, A and Ataei, Gh}, title = {Estimating the Absorbed Dose of Organs in Pediatric Imaging of 99mTc-DTPA Radiopharmaceutical using MIRDOSE Software}, journal = {Journal of Biomedical Physics and Engineering}, volume = {9}, number = {3}, pages = {285-294}, year = {2019}, publisher = {Shiraz University of Medical Sciences}, issn = {2251-7200}, eissn = {2251-7200}, doi = {10.31661/jbpe.v0i0.984}, abstract = {Introduction: In this study, organ radiation doses were calculated for the renal agent 99mTc-DTPA in children. Bio-kinetic energy of 99mTc-DTPA was evaluated by scintigraphy and estimates for absorbed radiation dose were provided using standard medical internal radiation dosimetry (MIRD) techniques.Material and Methods: In this applied research, fourteen children patients (6 males and 8 females) were imaged using a series of planar and SPECT images after injecting with technetium-99m diethylenetriaminepentaacetic acid (99mTc-DTPA). A hybrid planar/SPECT method was used to plot time-activity curves to obtain the residence time of the source organs and also MIRDOSE software was used to calculate the absorbed dose of every organ. P-values were calculated using t-tests in order to make a comparison between the adsorbed doses of male and female groups..Results: Mean absorbed doses (µGy/MBq) for urinary bladder wall, kidneys, gonads, liver and adrenals were 213.5±47.8, 12.97±6.23, 12.0±2.5, 4.29±1.47, and 3.31±0.96, respectively. Furthermore, the mean effective dose was 17.5±3.7 µSv/MBq. There was not any significant difference in the mean absorbed dose of the two groups.Conclusion: Bladder cumulated activity was the most contribution in the effective dose of patients scanned with 99mTc-DTPA. Using a hybrid planar/SPECT method can cause an increase in accumulated activity accuracy for the region of interest. Moreover, patient-specified internal dosimetry is recommended.}, keywords = {Internal Dosimetry,Hybrid Planar/SPECT Method,MIRDOSE Software,99mTc-DTPA}, url = {https://jbpe.sums.ac.ir/article_45748.html}, eprint = {https://jbpe.sums.ac.ir/article_45748_a98e02593576c25ed9fe25597b30e0a4.pdf} }