TY - JOUR ID - 43277 TI - In-vitro Study of Photothermal Anticancer Activity of Carboxylated Multiwalled Carbon Nanotubes JO - Journal of Biomedical Physics and Engineering JA - JBPE LA - en SN - AU - Bahreyni-Toosi, M H AU - Zare, M H AU - Ale davood, A AU - Shakeri, M T AU - Soudmand, S AD - Medical Physics Research Center, Medical Physics Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AD - Medical Physics Department, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran AD - Cancer Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AD - Department of Community Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AD - Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Y1 - 2017 PY - 2017 VL - 7 IS - 4 SP - 317 EP - 332 KW - Hyperthermia KW - Multiwalled Carbon Nanotubes KW - Nanoparticles KW - Near Infrared KW - Photothermal Therapy DO - N2 - Background and Objective: Multi-walled Carbon Nano Tubes (MWCNTs) as an important element of nanosciences have a remarkable absorption in the region of NIR window (650-900 nm) which can overcome the limitations of deep treatment in photothermal therapy. To disperse MWCNTs in water, it is proposed to attach carboxylated functional group (-COOH) to MWCNTs in order to increase dispersivity in water.Materials and Methods: A stable suspension of MWCNTs-COOH with different concentrations (from 2.5 to 500 μg/ml) was prepared. Then, they were compared for their ability to increase temperature in the presence of 810 nm laser irradiation and through a wide range of radiation time (from 20 to 600 s) and three laser powers (1.5, 2 and 2.5 w). The temperature rise was recorded real time every 20 seconds by a precise thermometer.Results: Absorption spectrum of MWCNTs-COOH suspension was remarkably higher than water in a wavelength range of 200 to 1100 nm. For example, using the concentrations of 2.5 and 80 μg/ml of MWCNTs-COOH suspension caused a temperature elevation 2.35 and 9.23 times compared to water, respectively, upon 10 min laser irradiation and 2.5 w. Moreover, this predominance can be observed for 1.5 and 2 w radiation powers, too. Our findings show that the maximum of temperature increase was obtained at 80 μg/ml concentration of MWCNT-COOH suspension for three powers and through all periods of exposure time. Our results show that the minimum required parameters for a 5°C temperature increase (a 5°C temperature increase causes cell death) were achieved through 2.5 w, 28 μg/ml concentration and 20 second irradiation time in which both concentration and radiation times were relatively low.Conclusion: Our results showed that MWCNTs-COOH can be considered as a potent photothermal agent in targeted therapies. New strategies must be developed to minimize the concentration, irradiation time and radiation power used in experiments. UR - https://jbpe.sums.ac.ir/article_43277.html L1 - https://jbpe.sums.ac.ir/article_43277_d7b94d27cef3aa473e2c2c37cd56caee.pdf ER -