Journal of Biomedical Physics and Engineering

Biosensing Based on Surface-Enhanced Raman Spectroscopy by Using Metal Nanoparticles

Document Type : Review Article

Authors

M. Saliminasab 1
A. R. Bahrampour 2
M. H. Zandi 3

1 Master of Science Student, Photonic Department, Kerman Graduate University of Technology, Kerman, Iran

2 Professor of Physics, Department of Physics, Sharif University of Technology, Tehran, Iran

3 Assistant Professor of Physics, Department of Physics, Shahid Bahonar University of Kerman, Kerman, Iran

Abstract
Surface-enhanced Raman spectroscopy (SERS) is a promising tool in the analytical science because it provides good selectivity and sensitivity without the labeling process required by fluorescence detection. This technique consists of locating the target analyte on nanometer range of roughed Au-nanoparticles. The presence of the metal nanoparticles provides a tremendous enhancement to the resulting Raman signal through an electromagnetic enhancement of both the laser excitation light and stokes-shifted light by 5–6 orders of magnitudes. SERS makes it possible to create a spectroscopic device that can act as a highly sensitive molecular detector using Raman signal as a fingerprint of the analyte. In this review, we present a general overview of the recent advancements in SERS as an analytical tool for identification of molecular species with concentrations below biological level in aqueous solution, with a particular attention to its potential applications in biomedicine.

Keywords

Analytes
Nanoparticles
Biosensor
Raman spectroscopy
Surface plasmon resonance

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