Journal of Biomedical Physics and Engineering

Changes of Cortisol and Glucose Concentrations in Rats Exposed to MR Imaging Field

Document Type : Original Research

Authors

D. Shahbazi-Gahrouei 1
F. Koohian 2
M. Koohian 3

1 Prof. of Medical Physics, Dept. of Medical Physics and Medical Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

2 PhD student of Medical Physics, Dept. of Medical Physics and Medical Engineering, School of Medicine, Isfahan Uni. of Medical Sciences.

3 MSc of Biochemistry, Dept. of Biology, Shahrekord University, Shahrekord, Iran.

Abstract
Background: MR imaging is one of the best diagnostic modalities in medicine. During an MR imaging examination, three types of field are employed to produce images. Various experimental studies have been performed about the effects of each single type of field but only few studies are available on their combination to generate MR imaging. The main objective of this research work is to study the effects of MR imaging on the level of glucose and cortisol hormone.Methods: 40 adult male Wistar rats (220 ± 10 g) were randomly divided into 2 groups of exposed (20) and control (20) groups. They were exposed under diagnostic MR imaging of 1.5 T field strengths for 25 minutes. Then, immediately blood samples were isolated and level of serum glucose measured by Auto-analyzer and cortisol content of blood sera was assayed by radioimmunoassay (RIA).Results: Findings showed significant decreases in the levels of glucose and cortisol hormone after 25 minutes of exposure.Conclusion: MR imaging may have adverse effects on the level of glucose and cortisol hormone.

Keywords

MRI
Cortisol
Glucose Concentration
Rats
Blood

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