Journal of Biomedical Physics and Engineering

The Mechanisms of Radiation-Induced Bystander Effect

Document Type : Blackboard

Authors

M Najafi 1
R Fardid 1
Gh Hadadi 1
M Fardid 2

1 department of radiology, school of paramedical sciences, shiraz university of medical sciences, shiraz, iran

2 Health Management and Economics Research Center, Iran University of Medical Science, Tehran, Iran.

Abstract
The radiation-induced bystander effect is the phenomenon which non-irradiated cells exhibit effects along with their different levels as a result of signals received from nearby irradiated cells. Responses of non-irradiated cells may include changes in process of translation, gene expression, cell proliferation, apoptosis and cells death. These changes are confirmed by results of some In-Vivo studies. Most well-known important factors affecting radiation-induced bystander effect include free radicals, immune system factors, expression changes of some genes involved in inflammation pathway and epigenetic factors.

Keywords

Bystander effect
Immune system
Free radicals
Mitochondria
Epigenetic
Journal of Biomedical Physics and Engineering
Volume 4, Issue 4 - Serial Number 4
14
November and December 2014

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