Journal of Biomedical Physics and Engineering

Protective Effects of IMOD and Cimetidine against Radiation-induced Cellular Damage

Document Type : Blackboard

Authors

S Rahgoshai 1
M Mohammadi 1
S Refahi 2
M Oladghaffari 3
S M R Aghamiri 4

1 Department of Medical radiation Science, School of Paramedicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Assistant Professor of Medical Physics, Department of Medical Physics, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran

3 Cellular & Molecular Biology Research Center, Medical Physics Department, Faculty of medicine, Babol University of Medical Sciences, Babol, Iran

4 Department of Radiation Medicine, Shahid Beheshti University of Medical Sciences,Tehran, Iran

Abstract
Radiation damage is to a large extent caused by overproduction of reactive oxygen species (ROS). Radioprotectors are agents or substances that reduce the effects of radiation in healthy normal tissues while maintaining the sensitivity to radiation damage in tumor cells.
Radioprotectors are agents or substances that reduce the effects of radiation in healthy normal tissues while maintaining the sensitivity to radiation damage in tumor cells
Cimetidine was found more effective when used in vivo; this effect might be due to the augmentation of the presence of Sulphur atom in the compound which is ‎important for their scavenging activity.
Recently, a new herbal-based medicine with immunomodulatory capacities, Setarud (IMOD), was introduced as an additional therapy in various inflammatory diseases and HIV infection.
IMOD is a mixture of herbal extracts enriched with selenium. Selenium confers protection by inducing or activating cellular free-radical scavenging systems and by enhancing peroxide breakdown. This article suggests that nontoxic amount of IMOD and cimetidine have radioprotective properties and could reduce cytotoxic effects of radiation.

Keywords

Radioprotection
Cimetidine
IMOD
Immunomodulator
Free Radical
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Journal of Biomedical Physics and Engineering
Volume 8, Issue 1 - Serial Number 1
27
Winter 2018
Pages 133-140

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