Document Type : Original Research
Authors
1 PhD of Medical Physics, Urmia University of Medical Science, School of Medicine, Urmia, Iran
2 PhD of Medical Physics, Urmia University of Medical Science, School of Para Medicine, Urmia, Iran
3 PhDs of Biostatics, Patient Safety Research Center, Urmia University of Medical Sciences, Urmia, Iran
4 MSc in Medical Physics, Urmia University of Medical Science, School of Medicine, Urmia, Iran
Abstract
Background: Gold nanoparticles (GNPs) are among the most promising radiosensitive materials in radiotherapy. Studying the effective sensitizing factors such as nanoparticle size, concentration, surface features, radiation energy and cell type can help to optimize the effect and possible clinical application of GNPs in radiation therapy. In this study, the radiation sensitive polymer gel was used to investigate the dosimetric effect of GNP size in megavoltage (MV) photon beam radiotherapy.
Material and Methods: GNPs with the size of 30nm, 50nm and 100nm in diameter were used. Transmission electron microscope (TEM) and dynamic light scattering (DLS) were applied to analyze the size of nanoparticles. The MAGICA polymer gel was synthesized and impregnated with different sizes of GNPs. The samples were irradiated with 6MV photon beam and 24 hours after irradiation, they were read using a Magnetic Resonance Imaging (MRI) scanner. Macroscopic Dose Enhancement Factor (DEF) was measured to compare the effect of GNP size. The MAGICA response of the 6MV x-ray beam was verified comparing Percentage Depth Dose (PDD) curve extracted from polymer gel dosimetry and Treatment Planning System (TPS).
Results: MAGICA polymer gel dose response curve was linear in the range of 0 to 10 Gy. DEFs by adding 30nm, 50nm and 100nm GNPs were 1.1, 1.17 and 1.12, respectively. PDD curves of polymer gel dosimeter and treatment planning system were in good agreement.
Conclusion: The results indicated a substantial increase in DEF uses a MV photon beam in combination with GNPs of different sizes and it was inconsistent with previous radiobiological studies. The maximum DEF was achieved for 50nm GNPs in comparison with 30nm and 100nm leading to the assumption of self-absorption effect by larger diameters. According to the outcomes of this work, MAGICA polymer gel can be recommended as a reliable dosimeter to investigate the dosimetric effect of GNP size and also a useful method to validate the current radiobiological and simulation studies.
Keywords
- Baskar R, Lee KA, Yeo R, Yeoh KW. Cancer and radiation therapy: current advances and future directions. Int J Med Sci. 2012;9:193-9. doi: 10.7150/ijms.3635. PubMed PMID: 22408567; PubMed Central PMCID: PMC3298009.
- Kwatra D, Venugopal A, Anant S. Nanoparticles in radiation therapy: a summary of various approaches to enhance radiosensitization in cancer. Translational Cancer Research. 2013;2:330-42.
- Jain S, Coulter JA, Hounsell AR, Butterworth KT, McMahon SJ, Hyland WB, et al. Cell-specific radiosensitization by gold nanoparticles at megavoltage radiation energies. Int J Radiat Oncol Biol Phys. 2011;79:531-9. doi: 10.1016/j.ijrobp.2010.08.044. PubMed PMID: 21095075; PubMed Central PMCID: PMC3015172.
- Jeremic B, Aguerri AR, Filipovic N. Radiosensitization by gold nanoparticles. Clinical and Translational Oncology. 2013;15:593-601.
- Su XY, Liu PD, Wu H, Gu N. Enhancement of radiosensitization by metal-based nanoparticles in cancer radiation therapy. Cancer Biol Med. 2014;11:86-91. doi: 10.7497/j.issn.2095-3941.2014.02.003. PubMed PMID: 25009750; PubMed Central PMCID: PMC4069802.
- Butterworth KT, McMahon SJ, Currell FJ, Prise KM. Physical basis and biological mechanisms of gold nanoparticle radiosensitization. Nanoscale. 2012;4:4830-8. doi: 10.1039/c2nr31227a. PubMed PMID: 22767423.
- Hainfeld JF, Dilmanian FA, Slatkin DN, Smilowitz HM. Radiotherapy enhancement with gold nanoparticles. J Pharm Pharmacol. 2008;60:977-85.
- Zhang XD, Wu D, Shen X, Chen J, Sun YM, Liu PX, et al. Size-dependent radiosensitization of PEG-coated gold nanoparticles for cancer radiation therapy. Biomaterials. 2012;33:6408-19. doi: 10.1016/j.biomaterials.2012.05.047. PubMed PMID: 22681980.
- Zhang XD, Wu D, Shen X, Liu PX, Yang N, Zhao B, et al. Size-dependent in vivo toxicity of PEG-coated gold nanoparticles. Int J Nanomedicine. 2011;6:2071-81. doi: 10.2147/IJN.S21657. PubMed PMID: 21976982; PubMed Central PMCID: PMC3181066.
- Chithrani DB, Jelveh S, Jalali F, van Prooijen M, Allen C, Bristow RG, et al. Gold nanoparticles as radiation sensitizers in cancer therapy. Radiat Res. 2010;173:719-28. doi: 10.1667/RR1984.1. PubMed PMID: 20518651.
- Lechtman E, Chattopadhyay N, Cai Z, Mashouf S, Reilly R, Pignol J. Implications on clinical scenario of gold nanoparticle radiosensitization in regards to photon energy, nanoparticle size, concentration and location. Phys Med Biol. 2011;56:4631-47.doi: 10.1088/0031-9155/56/15/001.
- Mesbahi A, Jamali F, Garehaghaji N. Effect of photon beam energy, gold nanoparticle size and concentration on the dose enhancement in radiation therapy. Bioimpacts. 2013;3:29-35. doi: 10.5681/bi.2013.002. PubMed PMID: 23678467; PubMed Central PMCID: PMC3648909.
- Marques T, Schwarcke M, Garrido C, Zucolot V, Baffa O, Nicolucci P, editors. Gel dosimetry analysis of gold nanoparticle application in kilovoltage radiation therapy. Journal of Physics: Conference Series; 2010. doi: 10.1088/1742-6596/250/1/012084.
- Rahman WN, Wong CJ, Ackerly T, Yagi N, Geso M. Polymer gels impregnated with gold nanoparticles implemented for measurements of radiation dose enhancement in synchrotron and conventional radiotherapy type beams. Australas Phys Eng Sci Med. 2012;35:301-9.doi: 10.1007/s13246-012-0157-x.
- Fong PM, Keil DC, Does MD, Gore JC. Polymer gels for magnetic resonance imaging of radiation dose distributions at normal room atmosphere. Phys Med Biol. 2001;46:3105-13.doi: 10.1088/0031-9155/46/12/303. PubMed PMID: 11768494.
- Zahmatkesh M, Kousari R, Akhlaghpour S, Bagheri S. MRI gel dosimetry with methacrylic acid, ascorbic acid, hydroquinone and copper in agarose (MAGICA) gel. Preliminary Proceedings of DOSGEL. 2004;2004.
- Meesat R, Jay-Gerin JP, Khalil A, Lepage M. Evaluation of the dose enhancement of iodinated compounds by polyacrylamide gel dosimetry. Phys Med Biol. 2009;54:5909-17. doi: 10.1088/0031-9155/54/19/016. PubMed PMID: 19759404.
- Baldock C, De Deene Y, Doran S, Ibbott G, Jirasek A, Lepage M, et al. Polymer gel dosimetry. Phys Med Biol. 2010;55:R1.
- Ibbott GS, editor Applications of gel dosimetry. Journal of Physics: conference series; 2004.
- Leung MK, Chow JC, Chithrani BD, Lee MJ, Oms B, Jaffray DA. Irradiation of gold nanoparticles by x-rays: Monte Carlo simulation of dose enhancements and the spatial properties of the secondary electrons production. Med Phys. 2011;38:624-31. doi: 10.1118/1.3539623. PubMed PMID: 21452700.
- McMahon SJ, Hyland WB, Muir MF, Coulter JA, Jain S, Butterworth KT, et al. Nanodosimetric effects of gold nanoparticles in megavoltage radiation therapy. Radiother Oncol. 2011;100:412-6. doi: 10.1016/j.radonc.2011.08.026. PubMed PMID: 21924786.
- Alqathami M, Blencowe A, Yeo UJ, Doran SJ, Qiao G, Geso M. Novel multicompartment 3-dimensional radiochromic radiation dosimeters for nanoparticle-enhanced radiation therapy dosimetry. International Journal of Radiation Oncology* Biology* Physics. 2012;84:e549-e55.doi: 10.1016/j.ijrobp.2012.05.029.
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