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Is Induction of Anomalies in Lymphocytes of the Residents of High Background Radiation Areas Associated with Increased Cancer Risk?

Document Type : Original Article

Authors

1 Professor of Medical Physics, Medical Physics Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

2 Ionizing and Non-ionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran

3 Student of Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

4 Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran

5 Assistant Professor of Oral and Maxillofacial Radiology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran

Abstract

Man has been exposed to different levels of natural background radiation since the creation of human life. There are inhabited areas around the world with extraordinary levels of natural background radiation. The level of natural radiation in these areas is up to two orders of magnitude higher than other places. Areas such as Yangjiang, China; Guarapari, Brazil; and Kerala, India are among the areas with high levels of natural radiation. Ramsar a coastal city in North Iran has some inhabited areas with the highest known levels of background radiation around the world. People who live in high background radiation areas (HBRAs) such as Ramsar do not record any detrimental biological effects. While some cytogenetic studies conducted in HBRAs have shown increased frequencies of unstable chromosome aberration, other investigations failed to find a significant difference. This short review is an attempt to verify if induction of chromosomal anomalies in the lymphocytes of the residents of high background radiation areas is associated with increased cancer risk.

Keywords

References
  1. Sutou S. A message to Fukushima: nothing to fear but fear itself. Genes Environ. 2016;38:12. doi.org/10.1186/s41021-016-0039-7. PubMed PMID: 27350831. PubMed PMCID: 4918197.
  2. Sohrabi M. World high background natural radiation areas: Need to protect public from radiation exposure. Radiation Measurements. 2013;50:166-71. doi.org/10.1016/j.radmeas.2012.03.011.
  3. Mortazavi S, Niroomand-Rad A, Roshan-Shomal P, Razavi-Toosi S, Mossayeb-Zadeh M, Moghadam M. Does short-term exposure to elevated levels of natural gamma radiation in Ramsar cause oxidative stress? Int J Appl Basic Med Res. 2014;4:72-6. doi.org/10.4103/2229-516X.136778. PubMed PMID: 25143879. PubMed PMCID: 4137645.
  4. Mortazavi S, Niroomand-Rad A, Mozdarani H, Roshan-Shomal P, Razavi-Toosi S, Zarghani H. Short-term exposure to high levels of natural external gamma radiation does not induce survival adaptive response. Int J Radiat Res. 2012;10:165-70.
  5. Mortazavi S, Ghiassi-Nejad M, Rezaiean M, editors. Cancer risk due to exposure to high levels of natural radon in the inhabitants of Ramsar, Iran. International Congress Series; 2005: Elsevier.
  6. Mortazavi S, Abbasi A, Asadi R, Hemmati A, editors. The need for considering social, economic, and psychological factors in warning the general public from the possible risks due to residing in HLNRAs. International Congress Series; 2005: Elsevier.
  7. Mortazavi S, Karam P. Apparent lack of radiation susceptibility among residents of the high background radiation area in Ramsar, Iran: can we relax our standards? Radioactivity in the Environment. 2005;7:1141-7. doi.org/10.1016/S1569-4860(04)07140-2.
  8. Taeb S, Mortazavi S, Ghaderi A, Mozdarani H, de Almeida C, Kardan M, et al. Alterations of PSA, CA15. 3, CA125, Cyfra21-1, CEA, CA19. 9, AFP and Tag72 tumor markers in human blood serum due to long term exposure to high levels of natural background radiation in Ramsar, Iran. Int J Radiat Res. 2014;12:133-8.
  9. Mortazavi S, Mozdarani H. Is it time to shed some light on the black box of health policies regarding the inhabitants of the high background radiation areas of Ramsar. Int J Radiat Res. 2012;10:111-6.
  10. Mortazavi S, Mozdarani H. Non-linear phenomena in biological findings of the residents of high background radiation areas of Ramsar. International Journal of Radiation Research. 2013;11:3-9.
  11. Ghiassi-nejad M, Mortazavi SM, Cameron JR, Niroomand-rad A, Karam PA. Very high background radiation areas of Ramsar, Iran: preliminary biological studies. Health Phys. 2002;82:87-93. doi.org/10.1097/00004032-200201000-00011. PubMed PMID: 11769138.
  12. Mortazavi S, Shabestani-Monfared A, Ghiassi-Nejad M, Mozdarani H, editors. Radioadaptive responses induced in lymphocytes of the inhabitants in Ramsar, Iran. International Congress Series; 2005: Elsevier.
  13. Mortazavi SMJ, Zarei S, Taheri M, Tajbakhsh S, Mortazavi SA, Ranjbar S, et al. Sensitivity to Antibiotics of Bacteria Exposed to Gamma Radiation Emitted from Hot Soils of the High Background Radiation Areas of Ramsar, Northern Iran. Int J Occup Environ Med. 2017;8:80-4. doi.org/10.15171/ijoem.2017.958. PubMed PMID: 28432369.
  14. Ghiassi-Nejad M, Zakeri F, Assaei RG, Kariminia A. Long-term immune and cytogenetic effects of high level natural radiation on Ramsar inhabitants in Iran. J Environ Radioact. 2004;74:107-16. doi.org/10.1016/j.jenvrad.2003.12.001. PubMed PMID: 15063540.
  15. Fazeli T, Assaei RG, Sohrabi M, Haydari A, Varzegar R, Zakeri F, et al. Cytogenetic studies of inhabitants of a high natural radiation area of Ramsar, Iran. Vienna: IAEA; 1990. p. 459-464.
  16. Hayata I, Wang C, Zhang W, Chen D, Minamihisamatsu M, Morishima H, et al. Effect of high-level natural radiation on chromosomes of residents in southern China. Cytogenet Genome Res. 2004;104:237-9. doi.org/10.1159/000077496. PubMed PMID: 15162045.
  17. Jiang T, Hayata I, Wang C, Nakai S, Yao S, Yuan Y, et al. Dose-effect relationship of dicentric and ring chromosomes in lymphocytes of individuals living in the high background radiation areas in China. J Radiat Res. 2000;41:63-8. doi.org/10.1269/jrr.41.S63. PubMed PMID: 11142213.
  18. Hayata I, Wang C-Y, Zhang W, Minamihisamatsu M, Chen D-Q, Morishima H, et al., editors. Chromosome translocation in residents of high background radiation area in China. International Congress Series; 2002: Elsevier.
  19. Wang C, Zhang W, Minamihisamatsu M, Morishima H, Yuan Y, Jiang T, et al., editors. Chromosome study in high background radiation area in Southern China. International Congress Series; 2005: Elsevier.
  20. Zhang W, Wang C, Chen D, Minamihisamatsu M, Morishima H, Yuan Y, et al. Effect of smoking on chromosomes compared with that of radiation in the residents of a high-background radiation area in China. J Radiat Res. 2004;45:441-6. doi.org/10.1269/jrr.45.441. PubMed PMID: 15613790.
  21. Hayata I, Wang C, Zhang W, Chen D, Minamihisamatsu M, Morishima H, et al. Chromosome translocation in residents of the high background radiation areas in southern China. J Radiat Res. 2000;41 Suppl:69-74. doi.org/10.1269/jrr.41.S69. PubMed PMID: 11142214.
  22. Zhang W, Wang C, Chen D, Minamihisamatsu M, Morishima H, Yuan Y, et al. Imperceptible effect of radiation based on stable type chromosome aberrations accumulated in the lymphocytes of residents in the high background radiation area in China. J Radiat Res. 2003;44:69-74. doi.org/10.1269/jrr.44.69. PubMed PMID: 12841602.
  23. Ramachandran EN, Karuppasamy CV, Cheriyan VD, Soren DC, Das B, Anilkumar V, et al. Cytogenetic studies on newborns from high and normal level natural radiation areas of Kerala in southwest coast of India. Int J Radiat Biol. 2013;89:259-67. doi.org/10.3109/09553002.2013.747014. PubMed PMID: 23134065.
  24. Chen D, Wei L. Chromosome aberration, cancer mortality and hormetic phenomena among inhabitants in areas of high background radiation in China. J Radiat Res. 1991;32 Suppl 2:46-53. doi.org/10.1269/jrr.32.SUPPLEMENT2_46. PubMed PMID: 1823366.
  25. Das B, Saini D, Seshadri M. No evidence of telomere length attrition in newborns from high level natural background radiation areas in Kerala coast, south west India. Int J Radiat Biol. 2012;88:642-7. doi.org/10.3109/09553002.2012.699135. PubMed PMID: 22668000.
  26. Das B, Saini D, Seshadri M. Telomere length in human adults and high level natural background radiation. PLoS One. 2009;4:e8440. doi.org/10.1371/journal.pone.0008440. PubMed PMID: 20037654. PubMed PMCID: 2793520.
  27. Jain V, Kumar PR, Koya PK, Jaikrishan G, Das B. Lack of increased DNA double-strand breaks in peripheral blood mononuclear cells of individuals from high level natural radiation areas of Kerala coast in India. Mutat Res. 2016;788:50-7. doi.org/10.1016/j.mrfmmm.2016.03.002. PubMed PMID: 27063255.
  28. Mohammadi S, Taghavi-Dehaghani M, Gharaati MR, Masoomi R, Ghiassi-Nejad M. Adaptive response of blood lymphocytes of inhabitants residing in high background radiation areas of ramsar- micronuclei, apoptosis and comet assays. J Radiat Res. 2006;47:279-85. doi.org/10.1269/jrr.0575. PubMed PMID: 16988494.
  29. Karuppasamy CV, Ramachandran EN, Kumar VA, Kumar PR, Koya PK, Jaikrishan G, et al. Peripheral blood lymphocyte micronucleus frequencies in men from areas of Kerala, India, with high vs normal levels of natural background ionizing radiation. Mutat Res Genet Toxicol Environ Mutagen. 2016;800-801:40-5. doi.org/10.1016/j.mrgentox.2016.03.005. PubMed PMID: 27085474.
  30. Das B. Genetic studies on human population residing in High Level Natural Radiation Areas of Kerala coast. BARC News letter. 2010:28-37.
  31. Das B, Karuppasamy CV. Spontaneous frequency of micronuclei among the newborns from high level natural radiation areas of Kerala in the southwest coast of India. Int J Radiat Biol. 2009;85:272-80. doi.org/10.1080/09553000902751462. PubMed PMID: 19296343.
  32. Masoomi JR, Mohammadi S, Amini M, Ghiassi-Nejad M. High background radiation areas of Ramsar in Iran: evaluation of DNA damage by alkaline single cell gel electrophoresis (SCGE). J Environ Radioact. 2006;86:176-86. doi.org/10.1016/j.jenvrad.2005.08.005. PubMed PMID: 16376699.
  33. Balachandar V, Kumar RK, Prakash V, Devi SM, Kumar BL, Manikantan P, et al. Evaluation of genetic alterations in inhabitants of a naturally high level background radiation and Kudankulam nuclear power project site in India. Asian Pac J Cancer Prev. 2011;12:35-41. PubMed PMID: 21517228.
  34. Nair RR, Rajan B, Akiba S, Jayalekshmi P, Nair MK, Gangadharan P, et al. Background radiation and cancer incidence in Kerala, India-Karanagappally cohort study. Health Phys. 2009;96:55-66. doi.org/10.1097/01.HP.0000327646.54923.11. PubMed PMID: 19066487.
  35. Gianferrari L, Serra A, Morganti G, Gualandri V, Bonino A. Mortality from cancer in an area of high background radiation. Bull World Health Organ. 1962;26:696-7. PubMed PMID: 13898293. PubMed PMCID: 2555782.
  36. Gopal-Ayengar A, Sundaram K, Mistry K, Sunta C. Evaluation of the long-term effects of high background radiation on selected population groups of the kerala coast. and others; Bhabha Atomic Research Centre, Bombay (India), 1971.
  37. Allwright SP, Colgan PA, McAulay IR, Mullins E. Natural background radiation and cancer mortality in the Republic of Ireland. Int J Epidemiol. 1983;12:414-8. doi.org/10.1093/ije/12.4.414. PubMed PMID: 6654560.
  38. Mosavi-Jarrahi A, Mohagheghi M, Akiba S, Yazdizadeh B, Motamedi N, Monfared AS, editors. Mortality and morbidity from cancer in the population exposed to high level of natural radiation area in Ramsar, Iran. International Congress Series; 2005: Elsevier.
  39. Mortazavi S, Ghiassi-Nejad M, Rezaiean M, editors. Cancer risk due to exposure to high levels of natural radon in the inhabitants of Ramsar, Iran. International Congress Series; 2005: Elsevier.
  40. Tao Z, Zha Y, Akiba S, Sun Q, Zou J, Li J, et al. Cancer mortality in the high background radiation areas of Yangjiang, China during the period between 1979 and 1995. J Radiat Res. 2000;41 Suppl:31-41. doi.org/10.1269/jrr.41.S31. PubMed PMID: 11142210.
  41. Tao Z, Akiba S, Zha Y, Sun Q, Zou J, Li J, et al. Cancer and non-cancer mortality among Inhabitants in the high background radiation area of Yangjiang, China (1979-1998). Health Phys. 2012;102:173-81. doi.org/10.1097/HP.0b013e31822c7f1e. PubMed PMID: 22217590.
  42. Zou J, Tao Z, Sun Q, Akiba S, Zha Y, Sugahara T, et al., editors. Cancer and non-cancer epidemiological study in the high background radiation area of Yangjiang, China. International Congress Series; 2005: Elsevier.
  43. Nair RR, Rajan B, Akiba S, Jayalekshmi P, Nair MK, Gangadharan P, et al. Background radiation and cancer incidence in Kerala, India-Karanagappally cohort study. Health Phys. 2009;96:55-66. doi.org/10.1097/01.HP.0000327646.54923.11. PubMed PMID: 19066487.
  44. Veiga LH, Koifman S, editors. Pattern of cancer mortality in some Brazilian HBRAs. International Congress Series; 2005: Elsevier.
  45. Mortazavi S, Mozdarani H. Can recent Berkeley findings help us to find a solution to the paradox of cancer incidence in high natural background radiation areas of Ramsar, Iran? Iranian Journal of Radiation Research (IJRR) . 2015;13(4):383-4.
  46. Mortazavi S, Zamani A, Tavakkoli-Golpayegani A, Taeb S. Development of a Preliminary Mathematical Model to Predict the Indoor Radon Concentration in Normal and High Background Radiation Areas of Ramsar. Soft Computing Applications: Springer; 2016. p. 373-7.
Journal of Biomedical Physics and Engineering
Volume 9, Issue 3 - Serial Number 3
33
May and June 2019
Pages 367-372
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