Document Type : Original Article
Authors
1 Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Department of Medical Physics, Tabriz University of Medical Sciences, Tabriz, Iran
3 Department of Inorganic Chemistry, Faculty of Chemistry, University of Tabriz, C.P. 51664, Tabriz, Iran
4 Department of MRI, Tabriz University of Medical Sciences, Tabriz, Iran
5 Department of Radiology, School of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract
Background: Magnetic resonance imaging (MRI) contrast agents have an important role to differentiate healthy and diseased tissues. Access and design new contrast agents for the optimal use of MRI are necessary. This study aims to evaluate iron oxide–4A nanocomposite ability to act as a magnetic resonance imaging contrast agent.
Material and Methods: Iron oxide–4A nanocomposite (F4A) was synthesized. MTT assay was used to consider the nanocomposite safety for cell culture. The T1 and T2 relaxation times were measured using a 1.5 Tesla clinical MRI scanner. Then the corresponding relaxivities were determined.
Results: The average particle diameter of the nanocomposite was 50 to 100 nm based on scanning electron microscope (SEM) image. A linear relationship between relaxation rates and the Fe concentration of the nanocomposite was obtained. The T1 and T2 relaxivities of the nanocomposite were calculated 5.413 and 1092.1 mM-1.s-1, respectively which led to the T2/T1 relaxivity ratio of 201.75.
Conclusion: The high T2/T1 relaxivity ratio of the iron oxide–4A nanocomposite confirms it’s potential to act as a T2 contrast agent.
Keywords
- Joshi HM. Multifunctional metal ferrite nanoparticles for MR imaging applications. J Nanopart Res. 2013;15:1235.
- Arsalani N, Fattahi H, Nazarpoor M. Synthesis and characterization of PVP-functionalized superparamagnetic Fe3O4 nanoparticles as an MRI contrast agent. Express Polym Lett. 2010;4:329-38. doi: 10.3144/expresspolymlett.2010.42.
- Wang YX. Superparamagnetic iron oxide based MRI contrast agents: Current status of clinical application. Quant Imaging Med Surg. 2011;1:35-40. doi: 10.3978/j.issn.2223-4292.2011.08.03. PubMed PMID: 23256052; PubMed Central PMCID: PMC3496483.
- Xiao YD, Paudel R, Liu J, Ma C, Zhang ZS, Zhou SK. MRI contrast agents: Classification and application (Review). Int J Mol Med. 2016;38:1319-26. doi: 10.3892/ijmm.2016.2744. PubMed PMID: 27666161.
- Corot C, Robert P, Idée JM, Port M. Recent advances in iron oxide nanocrystal technology for medical imaging. Adv Drug Deliv Rev. 2006;58:1471-504. DOI: 10.1016/j.addr.2006.09.013. PubMed PMID: 17116343.
- Rosen JE, Chan L, Shieh DB, Gu FX. Iron oxide nanoparticles for targeted cancer imaging and diagnostics. Nanomedicine. 2012;8:275-90. doi: 10.1016/j.nano.2011.08.017. PubMed PMID: 21930108.
- Bulte JW, Kraitchman DL. Iron oxide MR contrast agents for molecular and cellular imaging. NMR Biomed. 2004;17:484-99. doi: 10.1002/nbm.924. PubMed PMID: 15526347.
- Shukla S, Jadaun A, Arora V, Sinha RK, Biyani N, Jain VK. In vitro toxicity assessment of chitosan oligosaccharide coated iron oxide nanoparticles. Toxicol Rep. 2015;2:27-39. doi: 10.1016/j.toxrep.2014.11.002. PubMed PMID: 28962334; PubMed Central PMCID: PMC5598369.
- Di Marco M, Guilbert I, Port M, Robic C, Couvreur P, Dubernet C. Colloidal stability of ultrasmall superparamagnetic iron oxide (USPIO) particles with different coatings. Int J Pharm. 2007;331:197-203. doi: 10.1016/j.ijpharm.2006.11.002. PubMed PMID: 17141984.
- Oghabian MA, Gharehaghaji N, Masoudi A, Shanehsazzadeh S, Ahmadi R, Majidi RF, et al. Effect of coating materials on lymph nodes detection using magnetite nanoparticles. Advanced Science, Engineering and Medicine. 2013;5:37-45. doi: 10.1166/asem.2013.1214.
- Rivera A, Farıas T, Ruiz-Salvador A, De Menorval L. Preliminary characterization of drug support systems based on natural clinoptilolite. Microporous and Mesoporous Materials. 2003;61:249-59. doi: 10.1016/s1387-1811(03)00390-1.
- Khatamiana M, Divband B, Daryana M. Preparation, characterization and antimicrobial property of ag+-nano Chitosan/ZSM-5: novel Hybrid Biocomposites. Nanomedicine Journal. 2016;3:268-79.
- Bercoff PG, Bertorello HR, Saux C, Pierella LB, Botta PM, Kanazawa T, et al. Magnetic properties of Co-impregnated zeolites. Journal of Magnetism and Magnetic Materials. 2009;321:3813-20. doi: 10.1016/j.jmmm.2009.07.046.
- Khatamian M, Divband B, Farahmand-Zahed F. Synthesis and characterization of Zinc (II)-loaded Zeolite/Graphene oxide nanocomposite as a new drug carrier. Mater Sci Eng C Mater Biol Appl. 2016;66:251-8. doi: 10.1016/j.msec.2016.04.090. PubMed PMID: 27207061.
- Khatamian M, Divband B, Jodaei A. Degradation of 4-nitrophenol (4-NP) using ZnO nanoparticles supported on zeolites and modeling of experimental results by artificial neural networks. Mater Chem Phys. 2012;134:31-7. doi: 10.1016/j.matchemphys.2012.01.091.
- Young SW, Qing F, Rubin D, Balkus KJ, Jr., Engel JS, Lang J, et al. Gadolinium zeolite as an oral contrast agent for magnetic resonance imaging. J Magn Reson Imaging. 1995;5:499-508. PubMed PMID: 8574032.
- Norek M, Neves IC, Peters JA. 1H relaxivity of water in aqueous suspensions of Gd3+-loaded NaY nanozeolites and AlTUD-1 mesoporous material: the influence of Si/Al ratio and pore size. Inorg Chem. 2007;46:6190-6. doi: 10.1021/ic700699n.
- Liu CL, Peng YK, Chou SW, Tseng WH, Tseng YJ, Chen HC, et al. One-step, room-temperature synthesis of glutathione-capped iron-oxide nanoparticles and their application in in vivo T1-weighted magnetic resonance imaging. Small. 2014;10:3962-9. doi: 10.1002/smll.201303868.
- Dai L, Liu Y, Wang Z, Guo F, Shi D, Zhang B. One-pot facile synthesis of PEGylated superparamagnetic iron oxide nanoparticles for MRI contrast enhancement. Mater Sci Eng C Mater Biol Appl. 2014;41:161-7. doi: 10.1016/j.msec.2014.04.041. PubMed PMID: 24907749.
- Pereira C, Pereira AM, Rocha M, Freire C, Geraldes CF. Architectured design of superparamagnetic Fe 3 O 4 nanoparticles for application as MRI contrast agents: mastering size and magnetism for enhanced relaxivity. Journal of Materials Chemistry B. 2015;3:6261-73. doi: 10.1039/c5tb00789e.
)