Document Type : Original Research
Authors
- Azadeh Amraee 1
- Abolfazl Sarikhani 2
- Leili Darvish 3
- Zahr Alamzadeh 2
- Rasoul Irajirad 2
- Seyed Rabie Mahdavi 4
1 PhD Candidate, Department of Medical Physics, Iran University of Medical Sciences, Tehran, Iran
2 MSc, Finetech in Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran
3 PhD Candidate, Department of Medical Physics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4 PhD, Department of Medical Physics, Iran University of Medical Sciences, Tehran, Iran
Abstract
Background: The application of nanotechnology in the molecular diagnosis and treatment of cancer is essential.
Objective: This study aimed to investigate the influence of curcumin-coated ultra-small superparamagnetic iron oxide (USPIO) as a T1 contrast agent in Magnetic Resonance Imaging (MRI). .
Material and Methods: In this experimental study, the influence of curcumin-coated USPIO (Fe3O4@C) on the diagnosis of the cancer cell line was investigated. After synthesis, characterization, and relaxation of Fe3O4@C, the contrast changes in T1-weight MRI to mouse colon carcinoma 26 cell line were evaluated in vitro.
Results: Fe3O4@C nanoparticles (NPs) are good at imaging; based on a relaxometry test, the r1 and r2 relaxivities of Dotarem were 3.139 and 0.603 mM−1s−1, respectively. Additionally, the r1 and r2 relaxivities of Fe3O4@C were 3.792 and 1.3 mM−1s−1, respectively, with the rate of 2.155 of r2/r1 NPs.
Conclusion: The NPs can be identified as a positive contrast agent with a weight of T1 in MRI. The coresh-ell Fe3O4@C NPs can be effective in cancer treatment and diagnosis because of the therapeutic effects of curcumin and the properties of USPIO.
Keywords
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