Document Type : Original Research
Authors
- Omid Keshavarzi 1
- Gholamhassan Haddadi 1, 2
- Reza Fardid 1, 2
- Masoud Haghani Haghani 1, 2
- Tahereh Kalantari 3
- Azadeh Namdari 4
1 Department of Radiology, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
2 Ionizing and Nonionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran
3 Research Center for Diagnostic Laboratory Science and Technology, Faculty of Paramedicine, Shiraz University of Medical Sciences, Shiraz, Iran
4 Member of the Diagnostic Laboratory Science and Technology Research Center, Faculty of Paramedicine, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract
Background: Industrial radiography uses gamma or X-ray radionuclide sources to investigate the safety of industrial materials. Industrial radiation workers receive the highest occupational radiation doses.
Objective: The present study investigates the relationship between Bax and Bcl-2 gene expression variables in industrial radiation workers.
Material and Methods: In this case-control study, data was collected using blood sampling from 40 workers, including two groups of non-radiation and radiation workers employed at the location. Expression levels of Bax and Bcl-2 genes were assessed in the laboratory. The environmental and absorbed doses of workers were measured using environmental and pen dosimeters.
Results: Statistical analysis showed that the radiation group’s Bcl-2 gene expression level was significantly higher. Findings also demonstrated a correlation between Bcl-2 gene expression and the number of workdays. Also, the Bax gene expression did not show a significant change, and the expression ratio of Bax/Bcl-2 was insignificant in the two groups.
Conclusion: Exposure to low doses of radiation could promote an adaptive
response in cells by increasing Bcl-2 gene expression.
Keywords
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