Document Type : Commentary
Authors
1 Department of Nuclear Engineering, School of Mechanical Engineering, Shiraz University, Shiraz, Iran
2 Ionizing and Non-ionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran
3 Department of Medical Physics and Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
4 Department of Radiation Physics, Technische Universität Wien, Atominstitut, 1040 Vienna, Austria
5 Department of Chemistry and Chemical Engineering, Royal Military College of Canada, Kingston, ON, Canada
6 Department of Physics, East Carolina University, Greenville, NC 27858, USA
Abstract
Recent studies offer valuable insights into viral inactivation for vaccine development. Schulze et al. have demonstrated the potential of heavy ion beam irradiation to create effective vaccines, which is particularly relevant in the context of airborne pandemics. Notably, the success in immunizing mice via intranasal administration with the inactivated influenza virus is encouraging, especially given the genetic similarities between influenza and SARS-CoV-2. However, the study raises important considerations. While heavy ion treatment shows advantages, there are concerns about viral inactivation completeness and the potential for surviving viruses, albeit at extremely low levels. Prolonged irradiation times and the risk of selective pressure leading to the evolution of resistant variants are highlighted. Biosafety concerns regarding accidental lab escape of resistant strains are crucial, emphasizing the need for caution during experiments. Moreover, limitations in Monte Carlo simulations of virus irradiation are discussed, pointing out the need for more comprehensive studies to assess the impact of secondary particles on virus inactivation under realistic irradiation conditions. Given these considerations, while the study presents a promising approach for vaccine development, further research is essential to address potential drawbacks and optimize the method for safe and effective application.
Highlights
Seyed Mohammad Javad Mortazavi (Google Scholar)
Lembit Sihver (Google Scholar)
Keywords
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