Journal of Biomedical Physics and Engineering

Materials for Multimodal Medical Imaging Phantoms: A Comprehensive Review for Diagnostic and Training Applications

Articles in Press

Document Type : Review Article

Authors

Vasilev Yuri Alexandrovich 1
Cherkasskaya Marina Valeryevna 1
Leonov Denis Vladimirovich 1
Omelyanskaya Olga Vasilievna 1
Zhuhuang Zhou 2
José Francisco Silva Costa-Júnior 3

1 State Budget-Funded Health Care Institution of the City of Moscow “Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department”, Moscow, Russia

2 The Department of Biomedical Engineering, College of Chemistry and Life Science, Beijing University of Technology, Beijing, China

3 Postgraduate Program in Biomedical Engineering, Brazil University, São Paulo, Brazil

10.31661/jbpe.v0i0.2505-1931
Abstract
In diagnostic imaging, recent advances have introduced a wide range of modalities for diverse clinical applications, creating a growing need for anthropomorphic phantoms capable of supporting both single- and multimodal evaluations. Such phantoms play a crucial role in improving diagnostic accuracy, quality assurance, and medical training. This study aimed to identify and critically evaluate materials suitable for the construction of multimodal phantoms that realistically mimic human tissues. We systematically analyze materials to simulate biological tissues in multimodal test objects and to compare their signal characteristics with those of human tissues across various imaging combinations, including Computed Tomography/Magnetic Resonance Imaging (CT/MRI), Ultrasound (US)/MRI, US/CT, and CT/MRI/US. The advantages and limitations of the investigated materials are discussed, and promising directions for future development are highlighted. In addition, the feasibility of combining multiple materials within a single phantom is demonstrated. Our findings indicate that materials intended for large-scale phantom production must be safe, exhibit reproducible properties, and maintain stable imaging characteristics over time. The materials and design considerations presented in this study provide a foundation for the standardization of multimodal phantom development.

Keywords

Multimodal Imaging
Phantoms, Imaging
Magnetic Resonance Imaging
Tomography, X-Ray Computed
Journal of Biomedical Physics and Engineering

Articles in Press, Corrected Proof
Available Online from 08 July 2026

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