Journal of Biomedical Physics and Engineering

Enhancement of Toxic Substances Clearance from Blood Equvalent Solution and Human Whole Blood through High Flux Dialyzer by 1 MHz Ultrasound

Document Type : Original Research

Authors

M B Shiran 1
M Barzegar Marvasti 1
A Shakeri-Zadeh 1
M Shahidi 2
N Tabkhi 3
F Farkhondeh 1
E Kalantar 4
A Asadinejad 5

1 Department of Medical Physics, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

2 Department of Hematology, Faculty of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran

3 Company of Samin Teb Soroush (Smart), Tehran, Iran

4 Department of Immunology, Faculty of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran

5 Company of MEDITECHSYS, Tehran, Iran

Abstract
Background: Hemodialysis is a process of removing waste and excess fluid from blood when kidneys cannot function efficiently. It often involves diverting blood to the filter of the dialysis machin to be cleared of toxic substances. Fouling of pores in dialysis membrane caused by adhesion of plasma protein and other toxins will reduce the efficacy of the filtre.Objective: In This study, the influence of pulsed ultrasound waves on diffusion and the prevention of fouling in the filter membrane were investigated.Material and Methods: Pulsed ultrasound waves with frequency of 1 MHz at an intensity of 1 W/cm2 was applied to the high flux (PES 130) filter. Blood and blood equivalent solutions were passed through the filter in separate experimental setups. The amount of Creatinine, Urea and Inulin cleared from both blood equvalent solution and human whole blood passed through High Flux (PES 130) filter were measured in the presence and absence of ultrasound irradiation. Samples were taken from the outlet of the dialyzer every five minutes and the clearance of each constituent was calculated.Results: Statistical analysis of the blood equvalent solution and whole blood indicated the clearance of Urea and Inulin in the presence of ultrasound increased (p<0.05), while no significant effects were observed for Creatinine.Conclusion: It may be concluded that ultrasound, as a mechanical force, can increase the rate of clearance of some toxins (such as middle and large molecules) in the hemodialysis process.

Keywords

Ultrasound
High Flux Dialyzer
Creatinine
Urea
Inulin
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Journal of Biomedical Physics and Engineering
Volume 7, Issue 2 - Serial Number 2
24
May and June 2017
Pages 107-116

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