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Estimating the Absorbed Dose of Organs in Pediatric Imaging of 99mTc-DTPA Radiopharmaceutical using MIRDOSE Software

Document Type : Original Article

Authors

1 Department of Medical Physics Radiobiology and Radiation Protection, Babol University of Medical Sciences, Babol, Iran

2 Department of Medical Radiation, Science and Research Branch, Islamic Azad University, Tehran, Iran

3 Department of Medical Physics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

4 Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

5 Department of Radiology Technology, Faculty of Paramedical Sciences, Babol University of Medical Science, Babol, Iran

Abstract

Introduction: In this study, organ radiation doses were calculated for the renal agent 99mTc-DTPA in children. Bio-kinetic energy of 99mTc-DTPA was evaluated by scintigraphy and estimates for absorbed radiation dose were provided using standard medical internal radiation dosimetry (MIRD) techniques.Material and Methods: In this applied research, fourteen children patients (6 males and 8 females) were imaged using a series of planar and SPECT images after injecting with technetium-99m diethylenetriaminepentaacetic acid (99mTc-DTPA). A hybrid planar/SPECT method was used to plot time-activity curves to obtain the residence time of the source organs and also MIRDOSE software was used to calculate the absorbed dose of every organ. P-values were calculated using t-tests in order to make a comparison between the adsorbed doses of male and female groups..Results: Mean absorbed doses (µGy/MBq) for urinary bladder wall, kidneys, gonads, liver and adrenals were 213.5±47.8, 12.97±6.23, 12.0±2.5, 4.29±1.47, and 3.31±0.96, respectively. Furthermore, the mean effective dose was 17.5±3.7 µSv/MBq. There was not any significant difference in the mean absorbed dose of the two groups.Conclusion: Bladder cumulated activity was the most contribution in the effective dose of patients scanned with 99mTc-DTPA. Using a hybrid planar/SPECT method can cause an increase in accumulated activity accuracy for the region of interest. Moreover, patient-specified internal dosimetry is recommended.

Keywords

References
  1. Sgouros G, Frey E, Wahl R, He B, Prideaux A, Hobbs R. Three-dimensional imaging-based radiobiological dosimetry. Semin Nucl Med. 2008;38:321-34. doi: 10.1053/j.semnuclmed.2008.05.008. PubMed PMID: 18662554; PubMed Central PMCID: PMC2597292.
  2. Zanzonico PB. Internal radionuclide radiation dosimetry: a review of basic concepts and recent developments. J Nucl Med. 2000;41:297-308. PubMed PMID: 10688115.
  3. Sgouros G, Frey EC, Bolch WE, Wayson MB, Abadia AF, Treves ST. An approach for balancing diagnostic image quality with cancer risk: application to pediatric diagnostic imaging of 99mTc-dimercaptosuccinic acid. J Nucl Med. 2011;52:1923-9. doi: 10.2967/jnumed.111.092221. PubMed PMID: 22144506; PubMed Central PMCID: PMC3290866.
  4. Parach AA, Rajabi H, Askari MA. Assessment of MIRD data for internal dosimetry using the GATE Monte Carlo code. Radiat Environ Biophys. 2011;50:441-50. doi: 10.1007/s00411-011-0370-0. PubMed PMID: 21573984.
  5. Prideaux AR, Song H, Hobbs RF, He B, Frey EC, Ladenson PW, et al. Three-dimensional radiobiologic dosimetry: Application of radiobiologic modeling to patient-specific 3-dimensional imaging–based internal dosimetry. Journal of nuclear medicine: official publication, Society of Nuclear Medicine. 2007;48:1008.
  6. Momennezhad M, Nasseri S, Zakavi SR, Parach AA, Ghorbani M, Asl RG. A 3D Monte Carlo Method for Estimation of Patient-specific Internal Organs Absorbed Dose for (99m)Tc-hynic-Tyr(3)-octreotide Imaging. World J Nucl Med. 2016;15:114-23. doi: 10.4103/1450-1147.174700. PubMed PMID: 27134562; PubMed Central PMCID: PMC4809152.
  7. Goushbolagh NA, Farhood B, Astani A, Nikfarjam A, Kalantari M, Zare MH. Quantitative Cytotoxicity, Cellular Uptake and Radioprotection Effect of Cerium Oxide Nanoparticles in MRC-5 Normal Cells and MCF-7 Cancerous Cells. BioNanoScience. 2018:1-9.
  8. Stabin M. Nuclear medicine dosimetry. Phys Med Biol. 2006;51:R187-202. doi: 10.1088/0031-9155/51/13/R12. PubMed PMID: 16790903.
  9. Shahbazi-Gahrouei D, Nikzad S. Determination of organ doses in radioiodine therapy using medical internal radiation dosimetry (MIRD) method. Iran J Radiat Res. 2011;8:249-52.
  10. Chao TC, Xu XG. S-values calculated from a tomographic head/brain model for brain imaging. Phys Med Biol. 2004;49:4971-84.doi: 10.1088/0031-9155/49/21/009.PubMed PMID: 15584531.
  11. Stabin MG, Sparks RB, Crowe E. OLINDA/EXM: the second-generation personal computer software for internal dose assessment in nuclear medicine. J Nucl Med. 2005;46:1023-7. PubMed PMID: 15937315.
  12. Bagheri M, Razavi-Ratki S, Nafisi-Moghadam R, Jelodari M, Parach A. The Estimation of 99mtc DMSA Absorbed Dose in Renal Scintigraphy of Pediatric Patients Using MIRDOSE Software and Planar/SPECT Hybrid Method. SSU_Journals. 2016;24:649-58.
  13. Domingues FC, Fujikawa GY, Decker H, Alonso G, Pereira JC, Duarte PS. Comparison of relative renal function measured with either 99mTc-DTPA or 99mTc-EC dynamic scintigraphies with that measured with 99mTc-DMSA static scintigraphy. Int Braz J Urol. 2006;32:405-9.doi: 10.1590/s1677-55382006000400004.PubMed PMID: 16953906.
  14. Pirdamooie S, Shanei A, Moslehi M. Comparison of the absorbed dose for 99mTc-diethylenetriaminepentaacetic acid and 99mTc-ethylenedicysteine radiopharmaceuticals using medical internal radiation dosimetry. Journal of medical signals and sensors. 2015;5:171.doi: 10.4103/2228-7477.161489
  15. Siegel JA, Thomas SR, Stubbs JB, Stabin MG, Hays MT, Koral KF, et al. MIRD pamphlet no. 16: Techniques for quantitative radiopharmaceutical biodistribution data acquisition and analysis for use in human radiation dose estimates. J Nucl Med. 1999;40:37S-61S. PubMed PMID: 10025848.
  16. Lyra M, Lagopati N, Charalambatou P, Vamvakas I. Patient-specific dosimetry in radionuclide therapy. Radiat Prot Dosimetry. 2011;147:258-63. doi: 10.1093/rpd/ncr329. PubMed PMID: 21831867.
  17. Zeintl J, Vija AH, Yahil A, Hornegger J, Kuwert T. Quantitative accuracy of clinical 99mTc SPECT/CT using ordered-subset expectation maximization with 3-dimensional resolution recovery, attenuation, and scatter correction. J Nucl Med. 2010;51:921.doi: 10.2967/jnumed.109.071571.
  18. Grimes J, Celler A, Birkenfeld B, Shcherbinin S, Listewnik MH, Piwowarska-Bilska H, et al. Patient-specific radiation dosimetry of 99mTc-HYNIC-Tyr3-octreotide in neuroendocrine tumors. J Nucl Med. 2011;52:1474-81. doi: 10.2967/jnumed.111.088203. PubMed PMID: 21795364.
  19. Grimes J, Celler A. Comparison of internal dose estimates obtained using organ-level, voxel S value, and Monte Carlo techniques. Med Phys. 2014;41:092501. doi: 10.1118/1.4892606. PubMed PMID: 25186410.
  20. Bolch WE, Eckerman KF, Sgouros G, Thomas SR. MIRD pamphlet No. 21: a generalized schema for radiopharmaceutical dosimetry--standardization of nomenclature. J Nucl Med. 2009;50:477-84. doi: 10.2967/jnumed.108.056036. PubMed PMID: 19258258.
  21. Piepsz A, Ham HR. Pediatric applications of renal nuclear medicine. Semin Nucl Med. 2006;36:16-35. doi: 10.1053/j.semnuclmed.2005.08.002. PubMed PMID: 16356794.
  22. Dewaraja YK, Frey EC, Sgouros G, Brill AB, Roberson P, Zanzonico PB, et al. MIRD pamphlet no. 23: quantitative SPECT for patient-specific 3-dimensional dosimetry in internal radionuclide therapy. Journal of nuclear medicine: official publication, Society of Nuclear Medicine. 2012;53:1310.doi: 10.2967/jnumed.111.100123.
  23. Bagheri M, Parach AA, Razavi-Ratki SK, Nafisi-Moghadam R, Jelodari MA. PATIENT-SPECIFIC DOSIMETRY FOR PEDIATRIC IMAGING OF 99mTc-DIMERCAPTOSUCCINIC ACID WITH GATE MONTE CARLO CODE. Radiat Prot Dosimetry. 2018;178:213-22. doi: 10.1093/rpd/ncx101. PubMed PMID: 28981712.
  24. Razaq T, Nisar H, Roohi S, Shehzad A, Ahmad I. Administration of 99mTc-DTPA in combination with doxorubicin alters the radiopharmaceutical biodistribution in rats. Iranian Journal of Nuclear Medicine. 2017;25:122-8.
  25. Stabin M, Taylor JA, Eshima D, Wooter W. Radiation dosimetry for technetium-99m-MAG3, technetium-99m-DTPA, and iodine-131-OIH based on human biodistribution studies. Journal of nuclear medicine: official publication, Society of Nuclear Medicine. 1992;33:33-40.
  26. Lin KJ, Liu CY, Wey SP, Hsiao IT, Wu J, Fu YK, et al. Brain SPECT imaging and whole-body biodistribution with [(123)I]ADAM - a serotonin transporter radiotracer in healthy human subjects. Nucl Med Biol. 2006;33:193-202. doi: 10.1016/j.nucmedbio.2005.10.006. PubMed PMID: 16546673.
Journal of Biomedical Physics and Engineering
Volume 9, Issue 3 - Serial Number 3
33
May and June 2019
Pages 285-294
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